Metformin is a relatively safe drug with no major side effects that would help with insulin resistance and weight loss. For those who are seriously overweight metformin can be a useful tool to get the process started, but experts recommend that it should be discontinued as soon as the BMI has come below 35. A study a couple of years ago found that regular exercise and a low GI/GL diet were more effective than metformin anyway and without the nasty side effects. There are natural supplements like Chromium that also acts as blood sugar regulator and works similarly to Metformin, and in a much safe manner. If you are looking for metformin, specifically for weight loss, we recommend chromium supplements instead, like Phen375 and Instant Knockout. If you are diabetic, we recommend The Big Diabetes lie program.